Protein remodelling of the heart in NO-deficient hypertension: the effect of captopril

Pechánová O, Bernátová I, Pelouch V, Simko F. Protein remodelling of the heart in NO-deficient hypertension: the effect of captopril. J Mol Cell Cardiol. 1997 Dec;29(12):3365-74. doi: 10.1006/jmcc.1997.0566. PMID: 9441842.

The aim of the present study was to determine whether treatment with the angiotensin-converting enzyme inhibitor captopril can prevent hypertension, heart hypertrophy and changes in protein profile in NO-deficient hypertension.  We concluded that captopril prevented the development of hypertension, hypertrophy and diminished collagen concentration by mechanisms different from affecting NO-synthase activity.

https://pubmed.ncbi.nlm.nih.gov/9441842/