Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension

Pechánová O, Bernátová I, Babál P, Martínez MC, Kyselá S, Stvrtina S, Andriantsitohaina R. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens. 2004 Aug;22(8):1551-9. doi: 10.1097/01.hjh.0000133734.32125.c7. PMID: 15257179.

The effects  of red wine polyphenolic compounds on hemodynamic and functional cardiovascular changes during inhibition of nitric oxide (NO) synthesis have been studied. Our results showed that the beneficial effects of plant polyphenols in prevention of hypertension may result from their complex influence on the NO and ROS balance in the cardiovascular system. 

https://pubmed.ncbi.nlm.nih.gov/15257179/